Sunday, December 2, 2012

OUYA developer consoles shipping before the end of the year

OUYA

Gaming start-up OUYA today announced via its blog that it's planning on getting developer consoles to those who backed it at the developer level on Kickstarter by the end of the year. Dec. 28, in fact, is when OUYA says they'll leave the factory and still have that new-console smell. And apparently these early versions have something special in them -- "you'll know what I mean when you open yours," OUYA's JulesKane wrote. "They're rare drops."

In other news, account activation should happen by Christmas, OUYA says, and the team is still hard at work on the software side. Find the full post at the link below.

Source: OUYA



Source: http://feedproxy.google.com/~r/androidcentral/~3/HqHg5V_kTDw/story01.htm

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Novel studies of gene regulation in brain development may mean new treatment of mental disorders

ScienceDaily (Nov. 30, 2012) ? A team of researchers at the University of California, San Diego and the Institut Pasteur, Paris has come up with a novel way to describe a time-dependent brain development based on coherent-gene-groups (CGGs) and transcription-factors (TFs) hierarchy. The findings could lead to new drug designs for mental disorders such as autism-spectrum disorders (ASD) and schizophrenia.

In the paper, published November 22 as an online-first publication in the journal Genes, Brain and Behavior, the researchers identified the hierarchical tree of CGG-TF networks that determine the patterns of genes expressed during brain development and found that some "master transcription factors" at the top level of the hierarchy regulated the expression of a significant number of gene groups.

Instead of a taking the approach that a single gene creates a single response, researchers used contemporary methods of data analysis, along with the Gordon supercomputer at the university's San Diego Supercomputer Center (SDSC), to identify CGGs responsible for brain development which can be affected for treatment of mental disorders. The team found that these groups of genes act in concert to send signals at various levels of the hierarchy to other groups of genes, which control the general and more specific (depending of the level) events in brain structure development.

"We have proposed a novel, though still hypothetical, strategy of drug design based on this hierarchical network of TFs that could pave the way for a new category of pharmacological agents that could be used to block a pathway at a critical time during brain development as an effective way to treat and even prevent mental disorders such as ASD and schizophrenia," said lead author Igor Tsigelny, a research scientist with SDSC, as well as the university's Moores Cancer Center and Department of Neurosciences. "On a broader scale, these findings have the potential to change the paradigm of drug design."

Using samples taken from three different regions of the brains of rats, the researchers used Gordon and SDSC's BiologicalNetworks server to conduct numerous levels of analysis, starting with processing of microarray data and SOM (self-organizing maps) clustering, before determining which gene zones were associated with significant developmental changes and brain disorders.

Researchers then conducted analyses of stages of development and quick comparisons between rat and human brain development, in addition to pathway analyses and functional and hierarchical network analyses. The team then analyzed specific gene-TF interactions, with a focus on neurological disorders, before investigating further directions for drug design based on analysis of the hierarchical networks.

Tsigelny's collaborators included Valentina L. Kouzentsova (SDSC and Moores), Michael Baitaluk (SDSC); and Jean-Pierre Changeux, with the Institut Pasteur, in Paris, France. Changeux also is a Skaggs distinguished visiting professor in pharmacology at UC San Diego (2008) and a member of the foreign faculty at UC San Diego's Kavli Institute for Brain and Mind. In addition to SDSC and its computational resources, support for the research paper, called A Hierarchical Coherent-Gene-Group Model for Brain Development, was provided by National Institutes of Health grant # GM084881 for Baitaluk.

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The above story is reprinted from materials provided by University of California, San Diego, via Newswise.

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Journal Reference:

  1. Igor F. Tsigelny, Valentina L. Kouznetsova, Michael Baitaluk, Jean-Pierre Changeux. A hierarchical coherent-gene-group model for brain development. Genes, Brain and Behavior, 2012; DOI: 10.1111/gbb.12005

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_health/~3/2X_nTUcu3Eg/121130151612.htm

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University Of Wisconsin's Atheists, Humanists And Agnostics Group Scores Big Funding

(RNS) An organization of student nonbelievers is likely to receive $69,000 from the University of Wisconsin-Madison, the largest grant from an institute of higher learning ever awarded to a nontheistic, student-led organization.

The grant's size marks a milestone for UW's Atheists, Humanists and Agnostics -- AHA for short -- placing it in an elite group of large, student-run organizations eligible for UW funds, and making it the most well-funded atheist student group in the nation.

"This is unquestionably the most money an SSA group has ever received," said Jesse Galef, director of communications for Secular Student Alliance, an organization of 387 campus-based groups of nontheists, including AHA. "Over half our groups operate on $250 or less."

The grant has passed two approval stages and is awaiting approval from the university's student council, chancellor and regents. Rejection at this point is rare, said David Gardner, a spokesman for the university's student government association.

The money comes from a pot of $39 million garnered from student fees -- almost $1,400 per full-time student each year -- and distributed to fewer than two dozen large campus organizations. Other groups are eligible for money from a different fund.

But the money has strings. It must be used to provide services and programs UW does not. And those programs and services must be available year-round to all students -- not just ones who don't believe in God.

That's fine with Chris Calvey, president of AHA, which has about 1,500 names on its email list and attracts about 40 people to its meetings. He said much of the money will be used to hire eight staffers for a "secular support group," where students who do not believe in God or adhere to any religion could meet with like-minded students in a "safe" environment. A second planned program, a "faith questioning service," would allow students questioning religion to meet one-on-one with peers for discussion.

"We are not in the business of trying to go out and convert people to atheism," Calvey, a Ph.D. candidate in biology, said. "It is more about helping people find their own religious identities. If they grow stronger in their faith than they were before they talked to us, we think that's good too."

So far, AHA's award has met with no opposition -- university rules require overseers of the money to consider only the services the groups hope to provide.

"At no point in this process would anyone be able to say,'I don't like this group's viewpoint, so I don't want to fund them,'" Gardner said. "We take our neutrality very seriously."

Jake Heyka, president of Badger Catholic, a group that also receives university money, told the Milwaukee Journal Sentinel, "We absolutely respect the free will God granted us for individuals and groups to have an ideology that doesn't match our own."

When Calvey, 26, joined AHA in 2009, it had no budget. The following year, it applied for and received about $200 from the university, he said.

Each year, the group has applied for more funds for events, trips and educational programs. Last year's budget -- $15,000 -- went, in part, to co-sponsor a "Freethought Festival" with local, off-campus nontheistic groups that attracted more than 700 people. Part of the current grant would make AHA the sole sponsor of that annual event.

Galef, of SSA, called the grant a "game changer" for nontheistic students nationwide.

"It expands our sense of what's possible and shows us that the country is starting to give secular student alliances the same legitimacy religious groups have," he said.

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Source: http://www.huffingtonpost.com/2012/11/30/university-of-wisconsins-atheists-humanists-agnostics_n_2220814.html

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